Molecular Signatures Can Predict the Efficacy of Malaria Vaccines

A new study reveals that it is possible to identify those individuals that will be protected by the vaccine before its administration.

Molecular signatures before and after immunization can predict vaccine-induced protection, according to a study by ISGlobal, an institution supported by ”la Caixa” Foundation. The study analysed the gene expression in peripheral blood cells from individuals immunized with the first malaria vaccine (Mosquirix or RTS,S) and another experimental malaria vaccine.

The results, published in Science Translational Medicine suggest that boosting the immune system before vaccination could potentially improve vaccine efficacy.